Rabbit anti-Human Amyotrophic lateral sclerosis protein 2 (ALS2) IgG fraction polyclonal antibody

IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (LKACYYQIQREKLN) corresponding to amino acids 1644-1657 of human ALS2. The IgG fraction was purified using Protein G-Sepharose.

• Storage: Store at -20°C.
• Stability: Stable at least one year at -20°C. Avoid repeated freezing and thawing.
• Biological activity: This polyclonal antibody reacts in ELISA (1: 50 dilution) using the immunizing peptide. Amyotrophic lateral sclerosis protein 2 (ALS2) or Alsin is a 184 kDa protein that contains three guanine-nucleotide exchange factor domains and may act as a GTPase regulator. ALS2 dysfunction affects endosome trafficking through a Rab5 small GTPases family-mediated mechanism. It is a causative gene for a juvenile autosomal recessive form of motor neuron diseases, including amyotrophic lateral sclerosis 2. This disorder is characterized by a progressive degeneration of the upper motor neurons of the motor cortex and the lower motor neurons of the brain stem and spinal cord.
• Formulation: Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
• References: Yang, Y. et al. (2001) Nat. Genet. 29, 160-165. Hadano, S. et al. (20001) Nat. Genet. 166-173. Chandran, J. et al. (2007) Mol. Neurobiol. 224-231. Hadano, S. et al. (2007) Neurochem. Int. 51, 74-84.

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