Rabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody
1mg
$425.00
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Rabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody
Catalog no.
PN-7085a-9
$425.00
IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DLPNSGGEAQAKKLGNN) corresponding to amino acids 41-57 of human ERAB. The IgG fraction was purified using Protein G-Sepharose.
- Storage: Store at -20°C.
- Stability: Stable at least one year at -20°C. Avoid repeated freezing and thawing.
- Biological activity: This polyclonal antibody reacts in ELISA and Western blot assays (1: 1,000 dilution) using the immunizing peptide. Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27 kDa protein, member of the short-chain dehydrogenase/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients.
- Formulation: Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
- References: Yan, S.D. et al. (1997) Nature 389, 689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273, 10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451, 238-242.