Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)
50 µg
$275.00
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Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)
Catalog no.
MR-441-4
$275.00
IgG fraction from mouse monoclonal antibody (clone 6B1/E7) obtained by immunization of mice with the extra-cellular domain of interleukin 4 receptor alpha chain (38 kDa). The IgG fraction was purified using Protein G-Sepharose.
- Storage: Store at -20°C.
- Stability: Stable for at least one year. Avoid repeated freezing and thawing.
- Biological activity: This antibody can be used for ELISA assay (1:2,000 dilution). The IL-4R alpha chain binds both IL-4 and IL-13 and activates many common signal transduction pathways. The extra-cellular domain, also called CD124, inhibits IL-4-mediated cell proliferation and IL-5 up-regulation by T-cells. The IL-4/IL-13 responses are involved in the regulation of the differentiation of CD4+ T cells and class switching to IgG1 and IgE.
- Formulation: Solution at 0.95 mg/mL in PBS
- References: Nelms, K. et al. (1999) Annu. Rev. Immunol. 17, 701 - 738