Anti-Receptor-Interacting Serine/Threonine-Protein Kinase (RIP). IgG fraction (monoclonal)

IgG fraction from mouse monoclonal antibody (clone 9G11/G4) obtained by immunization of mice with the recombinant N-terminal region of RIP (aa1 - aa430). The IgG fraction was purified using Protein G-Sepharose.

• Storage: Store at -20°C.
• Stability: Stable for at least one year. Avoid repeated freezing and thawing.
• Biological activity: This antibody can be used for ELISA assay (1:8,000 dilution) and Western Blot (1: 12,000 dilution). RIP is a serine/threonine kinase, component of the active TNF receptor 1 signaling complex. It contains three domains, including an N-terminal kinase domain (aa1 – aa300), an intermediate domain, and a C-terminal death domain. This protein is essential in DNA damage-induced NF-?-B activation and in TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling.
• Formulation: Solution at 1.0 mg/mL in PBS
• References: Meylan, E. et al. (2004) Nat. Immunol. 5, 503 - 507.
  Zhang, H-G. et al. (2004) Oncogene 23, 2009 - 2015.
  Hur, G.M. et al. (2003) Genes & Dev. 17, 873 - 882.
  Hsu, H. et al. (1996) Immunity 4, 387 - 386.

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