Anti-Human Endogenous Retrovirus Type K (HERV K) Gag Protein, IgG Fraction, Monoclonal
100 µg
$425.00
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Anti-Human Endogenous Retrovirus Type K (HERV K) Gag Protein, IgG Fraction, Monoclonal
Catalog no.
HERM-1841-5
$425.00
IgG fraction from mouse monoclonal antibody (clone 4D4/F7) obtained by immunization of mice with HERV K gag antigen (82 kDa). The monoclonal antibody was purified using Protein G-Sepharose.
- Storage: Store at -20°C.
- Stability: Stable for at least one year. Avoid repeated freezing and thawing.
- Biological activity: This antibody can be used in ELISA assays (1:2,000 dilution) and Western Blot analysis (1:8,000 dilution). It recognizes HERV K gag and capsid antigens by Western Blot.
- Formulation: Solution at 0.5 mg/mL in PBS.
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References:
1. Toenjes, R.R. et al. (1997) Virology 233, 280 - 291.
2. Barbulescu, M. et al. (1999) Curr. Biol. 9, 861 - 868.
Publications using Austral Biologicals HERM-1841-5
The following scientific publications report experimental use of HERM-1841-5:
- HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer. Bonaventura et al., Journal for ImmunoTherapy of Cancer 13(8):e010099 (2025).
- Molecular architecture and conservation of an immature human endogenous retrovirus. Krebs et al., Nature Communications 14(1):5149 (2023).
- Resurrection of endogenous retroviruses during aging reinforces senescence. Liu et al., Cell 186(2):287-304.e26 (2023).
- Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma. Maze et al., Cancer Research 82(2):235-247 (2022).
- Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals. Contreras-Galindo et al., Journal of Virology 86(1):262-276 (2012).
- Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1. Gonzalez-Hernandez et al., Journal of Virology 86(15):7790-7805 (2012).
- HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. Jones et al., Journal of Clinical Investigation 122(12):4473-4489 (2012).
- Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element. George et al., Retrovirology 8:30 (2011).
- Expression of HERV-K correlates with status of MEK-ERK and p16INK4A-CDK4 pathways in melanoma cells. Li et al., Cancer Investigation 28(10):1031-1037 (2010).
- Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer. Contreras-Galindo et al., Journal of Virology 82(19):9329-9336 (2008).