Insulin-Like Growth Factor I (IGF-I), Human Recombinant

Publications using Austral Biologicals GF-050

The following scientific publications report use of Austral Biologicals GF-050:

1. The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques. Gude et al., Atherosclerosis Plus (2024).
2. Age and oxidative stress regulate Nrf2 homeostasis in human articular chondrocytes. Taylor et al., Osteoarthritis and Cartilage (2023).
3. Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes. Cui et al., Osteoarthritis and Cartilage (2023).
4. Evaluation of the Hypothalamic Kisspeptin System during the Attainment of Puberty in Gilts. Clapper et al., Open Journal of Animal Sciences 12:407-427 (2022).
5. Evaluation of the Hypothalamic Kisspeptin System throughout the Estrous Cycle in Gilts. Clapper et al., Open Journal of Animal Sciences 11:591-607 (2021).
6. Bedding Application to Feedlot Steers: Influence on Growth Performance, Estimated Maintenance Coefficient, Carcass Characteristics, and Circulating Metabolites in Beef Steers. Smerchek et al., Animals 10:1766 (2020).
7. Effects of increasing doses of trenbolone acetate and estradiol on finishing phase growth performance, carcass trait responses, and serum metabolites in beef steers following implantation. Smerchek et al., Translational Animal Science (2020).
8. IGF-1 increases production of extracellular matrix in human endplate chondrocytes via distinct signaling pathways. Zhang et al., International Journal of Clinical and Experimental Medicine 12:8831-8838 (2019).
9. Articular chondrocytes isolated from knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling. Collins et al., Osteoarthritis and Cartilage (2019).
10. The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals. Younis et al., Proceedings of the National Academy of Sciences 115:E2048-E2057 (2018).
11. High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes. Nazli et al., Osteoarthritis and Cartilage 25:1516-1521 (2017).
12. Effects of cinnamaldehyde or monensin on performance of weaned Holstein dairy heifers. Chapman et al., Journal of Dairy Science (2017).
13. Growth performance of calves fed microbially enhanced soy protein in pelleted starters. Senevirathne et al., Journal of Dairy Science (2017).
14. Evaluation of camelina meal as a feedstuff for growing dairy heifers. Lawrence et al., Journal of Dairy Science (2016).
15. Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations. Janssen et al., PLOS ONE 11:e0150453 (2016).
16. Effects of feeding rumen-degradable valine on milk production in late-lactating dairy cows. Hultquist and Casper, Journal of Dairy Science (2016).
17. Feeding fat from distillers dried grains with solubles to dairy heifers: II. Effects on metabolic profile. Anderson et al., Journal of Dairy Science (2015).
18. Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent. Greene and Loeser, Osteoarthritis and Cartilage (2015).
19. Effects of Short Term Administration of Genistein on Hypothalamic and Anterior Pituitary Hormones in Ovariectomized Gilts. Clapper and Paulson, Open Journal of Animal Sciences 5:163-173 (2015).
20. IGF-IR signal transduction protein content and its activation by IGF-I in human placentas: relationship with gestational age and birth weight. Iñiguez et al., PLOS ONE 9:e102252 (2014).
21. Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts. Thakur et al., PLOS ONE 8:e63838 (2013).
22. Concentrations of insulin glargine and its metabolites during long-term insulin therapy in type 2 diabetic patients and comparison of effects of insulin glargine, its metabolites, IGF-I, and human insulin on insulin and IGF-I receptor signaling. Varewijck et al., Diabetes 62:2539-2544 (2013).
23. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Yammani et al., Arthritis Research & Therapy 14:R23 (2012).
24. Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly. Varewijck et al., Diabetologia 55:1186-1194 (2012).
25. Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?. Bokov et al., PLOS ONE 6:e26891 (2011).
26. IGF-I/PI3K/Akt and IGF-I/MAPK/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder. Fuentes et al., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300:R1532-R1542 (2011).
27. Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro. Ocaranza et al., Journal of Hypertension 28:1054-1064 (2010).
28. PI3K p110α and p110β have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Matheny and Adamo, Cell Death & Differentiation (2010).
29. Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts. Matheny and Adamo, Biochemical and Biophysical Research Communications 390:252-257 (2009).
30. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-kinase-Akt and MEK-ERK MAPK signaling pathways. Yin et al., Journal of Biological Chemistry (2009).
31. Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts. Matheny and Adamo, Biochemical and Biophysical Research Communications 389:117-121 (2009).
32. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Cravero et al., Arthritis & Rheumatism (2009).
33. Vascularity and expression of angiogenic factors in bovine dominant follicles during the first follicular wave. Grazul-Bilska et al., Journal of Animal Science (2007).
34. NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. Yang et al., British Journal of Cancer (2006).
35. Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. Eisner et al., FEBS Letters 580:3469-3476 (2006).
36. Occupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle. Kuemmerle, American Journal of Physiology-Gastrointestinal and Liver Physiology 290:G1194-G1202 (2006).
37. Effects of decreased estradiol-17β on the serum and anterior pituitary IGF-I system in pigs. Hilleson-Gayne and Clapper, Journal of Endocrinology (2005).
38. Pro- and mature IGF-II during diet-induced weight loss in obese subjects. Espelund et al., European Journal of Endocrinology (2005).
39. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. Luo et al., Journal of Cell Biology (2005).
40. Role of Phosphoinositide 3-Kinase Regulatory Isoforms in Development and Actin Rearrangement. Brachmann et al., Molecular and Cellular Biology 25:2593-2606 (2005).
41. Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. Veldhuis et al., Journal of Clinical Endocrinology & Metabolism 90:2941-2947 (2005).
42. Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3β activity. Kuemmerle, American Journal of Physiology-Gastrointestinal and Liver Physiology 288:G101-G110 (2005).
43. Insulin-Like Growth Factor-Induced Transcriptional Activity of the Skeletal α-Actin Gene Is Regulated by Signaling Mechanisms Linked to Voltage-Gated Calcium Channels during Myoblast Differentiation. Spangenburg et al., Endocrinology 145:2054-2063 (2004).
44. Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes. Ibarra et al., Journal of Biological Chemistry (2004).
45. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Aki et al., Oncogene (2003).
46. Neuroprotective Effects of Insulin-Like Growth Factor-Binding Protein Ligand Inhibitors in Vitro and in Vivo. Mackay et al., Journal of Cerebral Blood Flow & Metabolism 23:1160-1167 (2003).
47. A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum. Chen et al., American Journal of Physiology-Endocrinology and Metabolism 284:E1149-E1155 (2003).
48. Administration of estradiol-17β increases anterior pituitary IGF-I and relative amounts of serum and anterior pituitary IGF-binding proteins in barrows. Rempel and Clapper, Journal of Animal Science (2002).
49. Regulation of IGFBP-4 levels in human intestinal muscle by an IGF-I-activated, confluence-dependent protease. Kuemmerle and Teng, American Journal of Physiology-Gastrointestinal and Liver Physiology 279:G975-G982 (2000).
50. IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle. Chakravarthy et al., Journal of Applied Physiology 89:1365-1379 (2000).
51. Serum concentrations of IGF-I, estradiol-17β, testosterone, and relative amounts of IGF-binding proteins in growing boars, barrows, and gilts. Clapper et al., Journal of Animal Science 78:2581-2588 (2000).
52. Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. Pereira et al., American Journal of Physiology-Endocrinology and Metabolism 279:E570-E576 (2000).
53. Leptin Expression Is Reduced with Acute Endotoxemia in the Pig: Correlation with Glucose, Insulin, and Insulin-like Growth Factor-1 (IGF-1). Leininger et al., Journal of Interferon & Cytokine Research 20:99-106 (2000).
54. Probing the Folding Pathways of Long R3 Insulin-like Growth Factor-I and Insulin-like Growth Factor-I via Disulfide Scrambling. Yang et al., Journal of Biological Chemistry 274:37598-37604 (1999).
55. Insulin-Like Growth Factor I Suppresses Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor Expression via a Mitogen-Activated Protein Kinase Pathway in UMR-106 Osteoblast-Like Cells. Kawane and Horiuchi, Endocrinology 140:871-879 (1999).
56. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. Gazzerro et al., Journal of Clinical Investigation 102:2106-2114 (1998).
57. Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. Gabbitas and Canalis, American Journal of Physiology-Endocrinology and Metabolism 275:E222-E228 (1998).
58. Insulin-related growth factors stimulate proliferation of retinal progenitors in the goldfish. Boucher and Hitchcock, Journal of Comparative Neurology 394:386-394 (1998).
59. Mitogen-Activated Protein Kinase Kinase Activity Is Required for Inhibition of Skeletal Muscle Differentiation by Insulin-Like Growth Factor 1 or Fibroblast Growth Factor 2. Weyman and Wolfman, Endocrinology 139:1794-1800 (1998).
60. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. Naito et al., American Journal of Physiology-Cell Physiology 274:C472-C480 (1998).
61. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. Wang et al., Journal of Clinical Investigation 100:1425-1439 (1997).
62. Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. Harrela et al., Journal of Clinical Investigation 98:2612-2615 (1996).
63. Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures. Teruel et al., Biochemical Journal 319:627-632 (1996).
64. Pro-inflammatory cytokines downregulate platelet derived growth factor-α receptor gene expression in human osteoblastic cells. Köse et al., Journal of Cellular Physiology 166:188-197 (1996).
65. c-erbA and v-erbA modulate growth and gene expression of a mouse glial precursor cell line. Iglesias et al., Cell Growth & Differentiation 5:697-704 (1994).