Interleukin-2 (IL-2), Human Recombinant

Human Interleukin-2 (IL-2) is a lymphokine which biological effects include activation and proliferation of T cells, B cells, and other lymphokine activated killer cells. Human IL-2 is composed of 133 amino acids, including 3 cysteine residues, two of which are involved in a disulfide bond essential for biological activity. Human and murine IL-2 are 62% homologous, and human IL-2 has been found to be active on murine cell lines. Human Interleukin-2 (RECOMBINANT) is produced in genetically engineered Escherichia coli cells, and purified by sequential chromatography.

• Molecular weight: 15 kDa
• Purity: Over 95% pure by SDS gel electrophoresis.
• Storage: Store at +2°C to +8°C
• Stability: Several months as formulated, at +2°C to +8°C.
• Biological activity: The biological activity is determined by a lymphocyte proliferation assay and each vial contains 160,000 IU (International units)
• Formulation: Lyophilized in the presence of stabilizer (mannitol), low levels of SDS (preventing aggregation), and Sodium Phosphate. It can be reconstituted in water giving a pH between 7.2-7.8. There are no preservatives in this formulation.
• References:
  
  1. Gillis, S., Ferm, M.M., Ou, W., and Smith, K.A., The Journal of Immunology, (1978) Vol 120, No. 6, June, 2027-2032
  2. Mosmann, T., Journal of Immunological Methods, (1983) Vol 65, 55-63

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