{"product_id":"tm-381","title":"Anti-Cyclin-dependent kinase 8 (CDK 8) IgG fraction (monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 9D5\/I7) obtained by immunization using a recombinant human CDK8. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used for ELISA analysis. CDK8 phosphorylates the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II. It is bound to and is activated by Cyclin C. CDK8 is involved in the control of cell cycle by transcriptional regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 0.5 mg\/mL in PBS (pH 7.2).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Tassan, J-P. et al. (1995) Proc. Natl. Acad. Sci. USA 92, 8871-8875.\u003cbr\u003eAkoulitchev, S. et al. (2000) Nature 407, 102 – 106.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_TM-381_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"150 µg","offer_id":52518884868398,"sku":"TM-381-55","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-tm-381-150ug.png?v=1788007935","url":"https:\/\/www.australbiologicals.com\/products\/tm-381","provider":"Austral Biologicals","version":"1.0","type":"link"}