{"product_id":"tm-1801z","title":"Anti-Dimethylated human Tumor Suppresor p53 IgG fraction (monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 2D12\/E8) obtained by immunization of mice with a KLH-conjugated synthetic peptide SHLKS [dimethyl-K]KGQST corresponding to aa367 – aa377 of human tumor suppressor p53. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes dimethylated p53 (K372). p53 is a transcription factor that is mutated in approximately half of all human cancers. It controls the cell cycle, apoptosis and DNA repair in response to cytotoxic stresses. The C terminus of p53 is rich in lysines, which are subjected to different modifications to regulate p53 activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Chuikov, S. et .al. (2004) Nature 432, 353 – 360 ; Hupp, T.R. et al. (1992) Cell 71, 875 – 886 ; Malkin, D. et al. (1990) Science 250, 1233 – 1238.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_TM-1801Z_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"150 µg","offer_id":52518884376878,"sku":"TM-1801Z-55","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-tm-1801z-150ug.png?v=1788007951","url":"https:\/\/www.australbiologicals.com\/products\/tm-1801z","provider":"Austral Biologicals","version":"1.0","type":"link"}