{"product_id":"tm-1201z","title":"Anti-human Suppressor of RNA Polymerase B (SRB7) IgG fraction(monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 5G12\/H8) obtained by immunization of mice with a recombinant human SRB7 (15 kDa). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA assays (1: 8,000 dilution) and Western blot (1: 8,000 dilution)). It recognizes human SRB7, an essential component of SRB7\/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Myers, L.C. \u0026amp; Kornberg, R. D. (2000) Annu. Rev. Biochem. 69, 729 – 749 ; Gu, W. et al. (1999) Mol. Cell 3, 97 – 108 ; Sun, X. et al. (1998) Mol. Cell 2, 213 – 222; Maldonado, E. et al. (1996) Nature 381, 86 – 89.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_TM-1201Z_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"150 µg","offer_id":52518884147502,"sku":"TM-1201Z-55","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-tm-1201z-150ug.png?v=1788007935","url":"https:\/\/www.australbiologicals.com\/products\/tm-1201z","provider":"Austral Biologicals","version":"1.0","type":"link"}