{"product_id":"tm-1101y","title":"Anti-human Histone Binding Protein or Retinoblastoma Binding Protein p46 (RBA p46) IgG fraction (monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 7F2\/F3) obtained by immunization of mice with histone binding protein p46 (46 kDa). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA assays (1: 4,000 dilution) and Western blot. It recognizes RbAp46, a nuclear histone-targeting subunit that target the NuRD (nucleosome remodeling histone deacetylase complex) and SIN3 complex (paired amphipathic helix domains) to their histone substrates regulated by nucleosomal DNA. NuRD is postulated to help maintain genes in a specific repressed state and SIN3 is involved in transcriptional repression. Both complexes also have specific functions in development\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Loyola, A. \u0026amp; Almouzni, G. (2004) Biochim. Biophys. Acta 1677, 3 – 11 ; Philpott, A. et al. (2000) Semin. Cell Dev. Biol. 11, 7 – 14; Ahringer, J. (2000) Trends Genet. 16, 351 – 356.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_TM-1101Y_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"150 µg","offer_id":52518884081966,"sku":"TM-1101Y-55","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-tm-1101y-150ug.png?v=1788008030","url":"https:\/\/www.australbiologicals.com\/products\/tm-1101y","provider":"Austral Biologicals","version":"1.0","type":"link"}