{"product_id":"tm-021x","title":"Anti-Excision Repair Cross Complement (ERCC2). IgG fraction (monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 2E11\/E8) obtained by immunization of mice with a peptide of ERCC2 (80 kDa subunit of TFIIH). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used for ELISA assay (1:8,000 dilution). It recognizes ERCC2 subunit of TFIIH and it has not cross reaction with ERCC3 subunit. ERCC2 is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH transcription factor. It is involved in nucleotide excision repair of DNA by opening around the damage, and the initiation of transcription catalyzed by RNA polymerase II.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 0.5 mg\/mL in PBS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Schultz, P. et al. (2000) Cell 105, 599 - 607.\u003cbr\u003eReardon, J.T. et al. (1996) Proc. Natl. Acad. Sci. USA 93 6482-\u003cbr\u003e6487.\u003cbr\u003eDrapkin, R. et al (1994) Nature 368, 769 - 772.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_TM-021X_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"150 µg","offer_id":52518883787054,"sku":"TM-021X-55","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-tm-021x-150ug.png?v=1788008056","url":"https:\/\/www.australbiologicals.com\/products\/tm-021x","provider":"Austral Biologicals","version":"1.0","type":"link"}