Rabbit anti-Human L-Myc IgG fraction polyclonal antibody
1mg
$425.00
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Rabbit anti-Human L-Myc IgG fraction polyclonal antibody
Catalog no.
PT-5010a-9
$425.00
IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (SQEEASERGPQE) corresponding to amino acids 224-235 of human L-Myc. The IgG fraction was purified using Protein G-Sepharose.
- Storage: Store at -20°C.
- Stability: Stable at least one year at -20°C. Avoid repeated freezing and thawing.
- Biological activity: This polyclonal antibody reacts in ELISA and Western blot assays (1: 100 dilution) using the immunizing peptide. L-Myc is a nuclear protein with two molecular forms of 60 and 66 kDa and it plays a role in the control of cell growth, cell cycle progression, neoplasia, and apoptotic cell death. It contains a basic helix-loop-helix leucine zipper domain required for dimerization and binds DNA as an heterodimer with Max protein. Both molecular forms have been detected in some carcinoma cell lines.
- Formulation: Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
- References: DePinho, R.A. et al. (1987) Genes & Dev. 1, 1311-1326. Nesbit, C-E. et al. (1999) Oncogene 18, 3004-3016. Knoepfler, P.S. et al. (2006) EMBO J. 25, 2723-2734.