{"product_id":"pn-7085a","title":"Rabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody","description":"\u003cp\u003eIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DLPNSGGEAQAKKLGNN) corresponding to amino acids 41-57 of human ERAB. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This polyclonal antibody reacts in ELISA and Western blot assays (1: 1,000 dilution) using the immunizing peptide. Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27 kDa protein, member of the short-chain dehydrogenase\/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1 mg\/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Yan, S.D. et al. (1997) Nature 389, 689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273, 10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451, 238-242.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_PN-7085A_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"1mg","offer_id":52517555536174,"sku":"PN-7085a-9","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-pn-7085a-1mg.png?v=1788008113","url":"https:\/\/www.australbiologicals.com\/products\/pn-7085a","provider":"Austral Biologicals","version":"1.0","type":"link"}