{"product_id":"pn-7070a","title":"Rabbit anti-Human Heregulin-1 (Neuregulin-1) precursor IgG fraction polyclonal antibody","description":"\u003cp\u003eIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AGRFSTQEEIQARLSSVIANQDPIAV) corresponding to amino acids 614 - 639 of human Heregulin-1. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Heregulin-1, also known as neu differentiation factor -2 (NDF) or Neuregulin-1(NRG1) plays an important role in regulating cell proliferation, metastasis, differentiation, and survival of varios normal and neoplastic tissues. It binds to c-erbB-3 and c-erbB-4 tyrosine kinase receptors, and has diverse functions in neural development and neuromuscular junctions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1 mg\/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Holmes, W.E. et al. (1992) Science 256, 1205 - 1210. Falls, D.L. (2003) Exp. Cell. Res. 284, 14 - 30. Esper, R.M. et al. (2006) Brain. Res. Rev. 51, 161 - 175.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_PN-7070A_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"1mg","offer_id":52517555372334,"sku":"PN-7070a-9","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-pn-7070a-1mg.png?v=1788008116","url":"https:\/\/www.australbiologicals.com\/products\/pn-7070a","provider":"Austral Biologicals","version":"1.0","type":"link"}