{"product_id":"pn-7040a","title":"Rabbit anti-Human Synphilin-1 (Alpha Synuclein-Interacting protein, SNCAIP) IgG fraction polyclonal antibody","description":"\u003cp\u003eIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (ASKGKNKAA) corresponding to amino acids 911 - 919 of human Synphilin-1. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Synphilin-1 is a cytoplasmatic protein that interacts with Alpha-Synuclein in neurons, and plays an important role in synaptic function, protein degradation and Lewy body formation. Mutation of this protein has a role in the formation of aggregates and cytotoxicity in Parkinson's disease by defective ubiquitination and \/or proteosomal inhibition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1 mg\/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Engelender, S. et al. (1999) Nat. Genet. 22, 110 - 114. Hrüger, R. (2004) Cell Tissue Res. 318, 195 - 199.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_PN-7040A_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"1mg","offer_id":52517555241262,"sku":"PN-7040a-9","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-pn-7040a-1mg.png?v=1788008117","url":"https:\/\/www.australbiologicals.com\/products\/pn-7040a","provider":"Austral Biologicals","version":"1.0","type":"link"}