Rabbit anti-Human Beta- Synuclein IgG fraction polyclonal antibody
1mg
$425.00
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Rabbit anti-Human Beta- Synuclein IgG fraction polyclonal antibody
Catalog no.
PN-7010a-9
$425.00
IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (IEPLMEPEGESYEDPPQE) corresponding to amino acids 108 - 125 of human Beta-Synuclein. The IgG fraction was purified using Protein G-Sepharose.
- Storage: Store at -20°C.
- Stability: Stable at least one year at -20°C. Avoid repeated freezing and thawing.
- Biological activity: This polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Human beta synuclein is a soluble protein highly abundant in presynaptic nerve terminals and a member of the synuclein family. It could act as a physiological negative regulator of Alpha-Synuclein aggregation and it is associated with neurodegenerative disordes.This protein has been shown to be a substrate for phosphorylation by CAM kinase.
- Formulation: Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
- References: Jakes, R. et al. (1994) FEBS Lett 345, 27 - 32. Clayton, D.F. & George, J.M. (1998) Trends Neurosci. 21 (6), 249 254. George, J.M. (2002) Genome Biol.3, 3002.1 - 3002.6. Masliah, E. & Hashimoto, M. (2002) Neurotoxicology 23, 461 - 468