{"product_id":"pca-3020a","title":"Rabbit anti-Human Cyclin-dependent Kinase 5 (Cdk5) (epitope a) IgG fraction polyclonal antibody","description":"\u003cp\u003eIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (MQKYEKLEKI) corresponding to amino acids 1-10 of human Cdk5. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This polyclonal antibody reacts in ELISA (1: 25 dilution) and Western blot (1:1,000 dilution) using the immunizing peptide. Cyclin-dependent kinase 5 (Cdk5) belongs to the Ser\/Thr protein kinase family. It is ubiquitously expressed in both cycling and noncycling cells but its activity is detected almost exclusively in brain extracts. Cdk5 is activated by p35 protein which is only expressed in the brain. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Pines, J. (1995) Biochem. J. 308, 697-711. Maccioni, R. et al. (2001) Eur. J. Biochem. 268, 1518-1527. O'Hare, M.J. et al. (2005) J. Neurosci. 25, 8954-8966. Angelo, M. et al. (2006) J. Neurochem. 99, 353-370.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_PCA-3020A_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"1mg","offer_id":52517554880814,"sku":"PCA-3020a-9","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-pca-3020a-1mg.png?v=1788008117","url":"https:\/\/www.australbiologicals.com\/products\/pca-3020a","provider":"Austral Biologicals","version":"1.0","type":"link"}