{"product_id":"pb-383","title":"Rabbit Anti-Human IGF-Binding Protein 6, IgG Fraction, Polyclonal","description":"\u003cp\u003eAnti-human IGF-Binding protein 6 IgG fraction is a polyclonal antibody raised in rabbit against purified human recombinant IGF-binding Protein 6. It is purified using Protein G.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e At least 1 year at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This polyclonal antibody recognizes human IGFBP-6, having a minor cross-reactivity with IGFBP-5 on a Western assay using a 1\/100 dilution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e IgG fraction. Frozen liquid. 1.0 mg\/mL. Formulated in 0.1 M Tris-HCl (pH 7.5)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-pb-383\"\u003ePublications using Austral Biologicals PB-383\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report use of the anti-IGFBP-6 polyclonal antibody from Austral Biologicals:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2013.04.018\" rel=\"noopener\" target=\"_blank\"\u003eIGF-II and IGFBP-6 regulate cellular contractility and proliferation in Dupuytren's disease\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eRaykha et al., Biochimica et Biophysica Acta - Molecular Basis of Disease 1832(10):1511-1519 (2013).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.fertnstert.2008.12.096\" rel=\"noopener\" target=\"_blank\"\u003eExpression of the insulin-like growth factor and insulin systems in the luteinizing macaque ovarian follicle\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eBrogan et al., Fertility and Sterility 93(5):1421-1429 (2010).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1074\/jbc.M804721200\" rel=\"noopener\" target=\"_blank\"\u003eRexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eUray et al., Journal of Biological Chemistry 284(1):345-353 (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1038\/sj.bjc.6602520\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation: implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKoike et al., British Journal of Cancer 92(8):1538-1544 (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1677\/joe.0.1720467\" rel=\"noopener\" target=\"_blank\"\u003eThe IGF system in neuroblastoma xenografts: focus on IGF-binding protein-6\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGrellier et al., Journal of Endocrinology 172(3):467-476 (2002).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1210\/endo.142.5.8140\" rel=\"noopener\" target=\"_blank\"\u003eCoordinated control of fetal gastric epithelial functions by insulin-like growth factors and their binding proteins\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTremblay et al., Endocrinology 142(5):1795-1803 (2001).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1165\/ajrcmb.23.3.4013\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSueoka et al., American Journal of Respiratory Cell and Molecular Biology 23(3):297-303 (2000).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1677\/joe.0.1630281\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-like growth factor binding proteins-2 to -6 are expressed by human vascular smooth muscle cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eAndersson et al., Journal of Endocrinology 163(2):281-288 (1999).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10383152\/\" rel=\"noopener\" target=\"_blank\"\u003eN-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eChambéry et al., Cancer Research 59(12):2898-2902 (1999).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1677\/joe.0.1570327\" rel=\"noopener\" target=\"_blank\"\u003eRegulation of IGF binding protein synthesis by a bovine mammary epithelial cell line\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eCohick and Turner, Journal of Endocrinology 157(2):327-336 (1998).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1677\/joe.0.1570013\" rel=\"noopener\" target=\"_blank\"\u003eModulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTucci et al., Journal of Endocrinology 157(1):13-24 (1998).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1095\/biolreprod55.4.803\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-like growth factor system in bovine first-wave dominant and subordinate follicles\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003ede la Sota et al., Biology of Reproduction 55(4):803-812 (1996).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_PB-383_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"1mg","offer_id":52517553144110,"sku":"PB-383-9","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-pb-383-1mg.png?v=1788008184","url":"https:\/\/www.australbiologicals.com\/products\/pb-383","provider":"Austral Biologicals","version":"1.0","type":"link"}