{"product_id":"mr-441","title":"Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 6B1\/E7) obtained by immunization of mice with the extra-cellular domain of interleukin 4 receptor alpha chain (38 kDa). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used for ELISA assay (1:2,000 dilution). The IL-4R alpha chain binds both IL-4 and IL-13 and activates many common signal transduction pathways. The extra-cellular domain, also called CD124, inhibits IL-4-mediated cell proliferation and IL-5 up-regulation by T-cells. The IL-4\/IL-13 responses are involved in the regulation of the differentiation of CD4+ T cells and class switching to IgG1 and IgE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 0.95 mg\/mL in PBS\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e Nelms, K. et al. (1999) Annu. Rev. Immunol. 17, 701 - 738\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_MR-441_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"50 µg","offer_id":52518882804014,"sku":"MR-441-4","price":275.0,"currency_code":"USD","in_stock":true},{"title":"250 µg","offer_id":52518882836782,"sku":"MR-441-7","price":400.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-mr-441-50ug.png?v=1788008266","url":"https:\/\/www.australbiologicals.com\/products\/mr-441","provider":"Austral Biologicals","version":"1.0","type":"link"}