{"product_id":"mi-290","title":"Human recombinant MIP-1 alpha","description":"\u003cp\u003eMacrophage Inflammatory Protein-1( (MIP-1 alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1 alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1 alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1 alpha is composed of 69 amino acid residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1 alpha is 60% homologous with human MIP-1 beta, 75% homologous with murine MIP-1 alpha, and has been shown to be active on murine cells. Human recombinant MIP-1 alpha is produced in genetically engineered yeast, and purified by sequential chromatography.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 8 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Over 95% pure by SDS gel electrophoresis, with low level of endotoxin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -80°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Several months at -80°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e In water at a concentration of 1.0 mg protein\/ml\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003c\/strong\u003e 1Nathan, C.F. (1987)J. Clin. Invest. 79:319\u003cbr\u003e2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612\u003cbr\u003e3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911\u003cbr\u003e2. Dunlop, et al (1992) Blood 79: 2221\u003cbr\u003e3. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_MI-290_Datasheet.pdf\" target=\"_blank\" rel=\"noopener\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"10 µg","offer_id":52518881886510,"sku":"MI-290-3","price":200.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":52518881919278,"sku":"MI-290-4","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-mi-290-10ug.png?v=1788008266","url":"https:\/\/www.australbiologicals.com\/products\/mi-290","provider":"Austral Biologicals","version":"1.0","type":"link"}