Anti-mouse Cripto-1 Protein (CR-1). IgG fraction (monoclonal)

IgG fraction from mouse monoclonal antibody (clone 8B10/H8) obtained by immunization of mice with Cripto-1 protein from mouse (27 kDa). The IgG fraction was purified using Protein G-Sepharose.

• Storage: Store at -20°C.
• Stability: Stable for at least one year. Avoid repeated freezing and thawing.
• Biological activity: This antibody can be used for ELISA assay (1:8,000). It recognizes mouse Cripto protein. Cripto-1 is a signaling protein and member of the epidermal growth factor protein family. It plays an important role during early embryonic development. It has also a role in tumor development, induces cell proliferation, reduces apoptosis and increases cell migration. Cripto-1 is released or shed from expressing cells and may serve as marker gene in the early to mid-progressive stages of a variety carcinomas.
• Formulation: Solution at 0.5 mg/mL in PBS
• References: Strizzi, L. et al. (2004) J. Cell. Physiol. 201, 266 - 276.
  Adamson, E.D. et al. (2002) J. Cell. Physiol. 190, 267 - 278.
  Minchiotti, G. et al. (2002) Gene 287, 33 - 37.
  Persico, M.G. et al. (2001) Biochim. Biophys. Acta 1552, 87 - 93
  Salomon, D.S. et al. (2000) Endocr. Relat. Cancer 7, 199 - 226.

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