{"product_id":"hnm-6052az1","title":"Anti-Glycoprotein 1 of Hantaan Virus (HTNV), IgG fraction, Monoclonal, Clone 1F5\/G2","description":"\u003cp\u003eMouse monoclonal antibody IgG fraction (clone 1F5\/G2) obtained by immunizing mice with purified recombinant HTNV Glycoprotein 1 µg1). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA (1:30,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of HTNV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. HTNV is a causative agent of severe hemorrhagic fever mainly in China and it is transmitted by the rodent Apodemus agrarius.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-hnm-6052az1\"\u003ePublications using HNM-6052AZ1\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report use of this Austral Biologicals product:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/mbio.02372-18\" rel=\"noopener\" target=\"_blank\"\u003eTwo Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSlough et al., mBio 10(1):e02372-18 (2019).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518877954350,"sku":"HNM-6052AZ1-5","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-hnm-6052az1-100ug.png?v=1788008453","url":"https:\/\/www.australbiologicals.com\/products\/hnm-6052az1","provider":"Austral Biologicals","version":"1.0","type":"link"}