{"product_id":"hnm-6042az1","title":"Anti-Glycoprotein 1 of Seoul Virus (SEOV), IgG Fraction, Monoclonal, Clone 2C8\/B11","description":"\u003cp\u003eMouse monoclonal antibody IgG fraction (clone 2C8\/B11) obtained by immunizing mice with purified recombinant SEOV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA (1:10,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of SEOV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. SEOV is a hantavirus causing a mild to moderate form of hemorrhagic fever with renal syndrome that is distributed mainly in Asia and Europe. It is transmitted by the rodents Rattus rattus and Rattus norvegicus.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Zhang, Y-Z et al. (2009) Emerg. Infect. Dis. 15, 200-206.\u003cbr\u003e2. Lokugamage, N. et al. (2004) Microbiol. Immunol. 48, 843-851.\u003cbr\u003e3. Kim, Y.S. et al. (1995) Nephon 71, 419-427.\u003cbr\u003e4. Antic, D. et al. (1991) Virus Res. 19, 47-58.\u003cbr\u003e5. Arikawa, J. et al. (1990) Virology 176, 114-125.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_HNM-6042AZ1_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518877888814,"sku":"HNM-6042AZ1-5","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-hnm-6042az1-100ug.png?v=1788008444","url":"https:\/\/www.australbiologicals.com\/products\/hnm-6042az1","provider":"Austral Biologicals","version":"1.0","type":"link"}