{"product_id":"herm-1841","title":"Anti-Human Endogenous Retrovirus Type K (HERV K) Gag Protein, IgG Fraction, Monoclonal","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 4D4\/F7) obtained by immunization of mice with HERV K gag antigen (82 kDa). The monoclonal antibody was purified using Protein G-Sepharose.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA assays (1:2,000 dilution) and Western Blot analysis (1:8,000 dilution). It recognizes HERV K gag and capsid antigens by Western Blot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 0.5 mg\/mL in PBS.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Toenjes, R.R. et al. (1997) Virology 233, 280 - 291.\u003cbr\u003e2. Barbulescu, M. et al. (1999) Curr. Biol. 9, 861 - 868.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-herm-1841\"\u003ePublications using Austral Biologicals HERM-1841-5\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report experimental use of HERM-1841-5:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1136\/jitc-2024-010099\" rel=\"noopener\" target=\"_blank\"\u003eHERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eBonaventura et al., Journal for ImmunoTherapy of Cancer 13(8):e010099 (2025).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1038\/s41467-023-40786-w\" rel=\"noopener\" target=\"_blank\"\u003eMolecular architecture and conservation of an immature human endogenous retrovirus\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKrebs et al., Nature Communications 14(1):5149 (2023).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.cell.2022.12.017\" rel=\"noopener\" target=\"_blank\"\u003eResurrection of endogenous retroviruses during aging reinforces senescence\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eLiu et al., Cell 186(2):287-304.e26 (2023).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-3857\" rel=\"noopener\" target=\"_blank\"\u003eHuman Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMaze et al., Cancer Research 82(2):235-247 (2022).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00602-11\" rel=\"noopener\" target=\"_blank\"\u003eCharacterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eContreras-Galindo et al., Journal of Virology 86(1):262-276 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.07215-11\" rel=\"noopener\" target=\"_blank\"\u003eExpression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGonzalez-Hernandez et al., Journal of Virology 86(15):7790-7805 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1172\/JCI64560\" rel=\"noopener\" target=\"_blank\"\u003eHERV-K-specific T cells eliminate diverse HIV-1\/2 and SIV primary isolates\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eJones et al., Journal of Clinical Investigation 122(12):4473-4489 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1186\/1742-4690-8-30\" rel=\"noopener\" target=\"_blank\"\u003eIdentification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGeorge et al., Retrovirology 8:30 (2011).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3109\/07357907.2010.512604\" rel=\"noopener\" target=\"_blank\"\u003eExpression of HERV-K correlates with status of MEK-ERK and p16INK4A-CDK4 pathways in melanoma cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eLi et al., Cancer Investigation 28(10):1031-1037 (2010).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00646-08\" rel=\"noopener\" target=\"_blank\"\u003eHuman Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eContreras-Galindo et al., Journal of Virology 82(19):9329-9336 (2008).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_HERM-1841_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518876217646,"sku":"HERM-1841-5","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-herm-1841-100ug.png?v=1788008495","url":"https:\/\/www.australbiologicals.com\/products\/herm-1841","provider":"Austral Biologicals","version":"1.0","type":"link"}