{"product_id":"herm-1811","title":"Anti-Human Endogenous Retrovirus Type K (HERV K) Envelope Protein, IgG Fraction, Monoclonal","description":"\u003cp\u003eIgG fraction from mouse monoclonal antibody (clone 2I5\/H4) obtained by immunization of mice with HERV K envelope antigen (79.5 kDa). The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable for at least one year. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA assays (1:8,000 dilution).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Toenjes, R.R. et al. (1997) Virology 233, 280 - 291.\u003cbr\u003e2. Barbulescu, M. et al. (1999) Curr. Biol. 9, 861 - 868.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-herm-1811\"\u003ePublications using Austral Biologicals HERM-1811-5\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report experimental use of HERM-1811:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-25-2437\" rel=\"noopener\" target=\"_blank\"\u003eTargeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eFeng et al., Cancer Research 86(14):3588-3603 (2026).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.125.074845\" rel=\"noopener\" target=\"_blank\"\u003eAn Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eXiong et al., Circulation 152(13):939-956 (2025).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1126\/sciadv.ady8168\" rel=\"noopener\" target=\"_blank\"\u003eHuman endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eShek et al., Science Advances 11(35):eady8168 (2025).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1093\/procel\/pwaf025\" rel=\"noopener\" target=\"_blank\"\u003eSingle-nucleus transcriptomics decodes the link between aging and lumbar disc herniation\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eWang et al., Protein \u0026amp; Cell 16(8):667-684 (2025).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.cell.2022.12.017\" rel=\"noopener\" target=\"_blank\"\u003eResurrection of endogenous retroviruses during aging reinforces senescence\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eLiu et al., Cell 186(2):287-304.e26 (2023).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1164\/rccm.202102-0446OC\" rel=\"noopener\" target=\"_blank\"\u003eEndogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTaylor et al., American Journal of Respiratory and Critical Care Medicine 206(8):1019-1034 (2022).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-3857\" rel=\"noopener\" target=\"_blank\"\u003eHuman Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMaze et al., Cancer Research 82(2):235-247 (2022).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3390\/ijms222212398\" rel=\"noopener\" target=\"_blank\"\u003eA Comprehensive Analysis of Human Endogenous Retroviruses HERV-K (HML.2) from Teratocarcinoma Cell Lines and Detection of Viral Cargo in Microvesicles\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMorozov and Morozov, International Journal of Molecular Sciences 22(22):12398 (2021).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.5483\/BMBRep.2021.54.7.246\" rel=\"noopener\" target=\"_blank\"\u003eExpression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKo et al., BMB Reports 54(7):368-373 (2021).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1186\/s13100-020-0204-1\" rel=\"noopener\" target=\"_blank\"\u003eCharacterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTatkiewicz et al., Mobile DNA 11:9 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3390\/ijms21217855\" rel=\"noopener\" target=\"_blank\"\u003eFormation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGröger et al., International Journal of Molecular Sciences 21(21):7855 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1073\/pnas.2005237117\" rel=\"noopener\" target=\"_blank\"\u003ePosttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eForoushani et al., Proceedings of the National Academy of Sciences 117(42):26520-26530 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1126\/sciadv.aba3200\" rel=\"noopener\" target=\"_blank\"\u003ePrimate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTurelli et al., Science Advances 6(35):eaba3200 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1073\/pnas.2002427117\" rel=\"noopener\" target=\"_blank\"\u003eRegulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eWang et al., Proceedings of the National Academy of Sciences 117(30):17842-17853 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3390\/v10080412\" rel=\"noopener\" target=\"_blank\"\u003eDisruption by SaCas9 Endonuclease of HERV-K env, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eIbba et al., Viruses 10(8):412 (2018).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.ppat.1007123\" rel=\"noopener\" target=\"_blank\"\u003eReconstruction of the cell entry pathway of an extinct virus\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eRobinson-McCarthy et al., PLOS Pathogens 14(8):e1007123 (2018).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.7554\/eLife.35989\" rel=\"noopener\" target=\"_blank\"\u003eSystematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eFuentes et al., eLife 7:e35989 (2018).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1186\/s13024-018-0275-3\" rel=\"noopener\" target=\"_blank\"\u003eTranscriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMayer et al., Molecular Neurodegeneration 13(1):39 (2018).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.virol.2017.06.004\" rel=\"noopener\" target=\"_blank\"\u003eExpression of HERV-K108 envelope interferes with HIV-1 production\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTerry et al., Virology 509:52-59 (2017).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.03136-15\" rel=\"noopener\" target=\"_blank\"\u003eInfectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eRobinson and Whelan, Journal of Virology 90(7):3640-3649 (2016).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00544-15\" rel=\"noopener\" target=\"_blank\"\u003eHuman Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eContreras-Galindo et al., Journal of Virology 89(14):7187-7201 (2015).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4049\/jimmunol.1302108\" rel=\"noopener\" target=\"_blank\"\u003eCutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMichaud et al., Journal of Immunology 193(4):1544-1548 (2014).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00669-14\" rel=\"noopener\" target=\"_blank\"\u003eHIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eBrinzevich et al., Journal of Virology 88(11):6213-6223 (2014).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1186\/1742-4690-11-10\" rel=\"noopener\" target=\"_blank\"\u003eTrans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMichaud et al., Retrovirology 11:10 (2014).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4103\/1477-3163.109032\" rel=\"noopener\" target=\"_blank\"\u003eHuman endogenous retroviral K element encodes fusogenic activity in melanoma cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eHuang et al., Journal of Carcinogenesis 12:5 (2013).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0072756\" rel=\"noopener\" target=\"_blank\"\u003eVaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKraus et al., PLOS ONE 8(8):e72756 (2013).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00602-11\" rel=\"noopener\" target=\"_blank\"\u003eCharacterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eContreras-Galindo et al., Journal of Virology 86(1):262-276 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1172\/JCI64560\" rel=\"noopener\" target=\"_blank\"\u003eHERV-K-specific T cells eliminate diverse HIV-1\/2 and SIV primary isolates\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eJones et al., Journal of Clinical Investigation 122(12):4473-4489 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4049\/jimmunol.1200079\" rel=\"noopener\" target=\"_blank\"\u003eVaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSacha et al., Journal of Immunology 189(3):1467-1479 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jri.2011.06.102\" rel=\"noopener\" target=\"_blank\"\u003eHuman endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKämmerer et al., Journal of Reproductive Immunology 91(1-2):1-8 (2011).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.01368-09\" rel=\"noopener\" target=\"_blank\"\u003eReconstitution of the ancestral glycoprotein of human endogenous retrovirus K and modulation of its functional activity by truncation of the cytoplasmic domain\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eHanke et al., Journal of Virology 83(24):12790-12800 (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.yexcr.2008.12.023\" rel=\"noopener\" target=\"_blank\"\u003eThe activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSerafino et al., Experimental Cell Research 315(5):849-862 (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/JVI.00646-08\" rel=\"noopener\" target=\"_blank\"\u003eHuman Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eContreras-Galindo et al., Journal of Virology 82(19):9329-9336 (2008).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_HERM-1811_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518876119342,"sku":"HERM-1811-5","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-herm-1811-100ug.png?v=1788008512","url":"https:\/\/www.australbiologicals.com\/products\/herm-1811","provider":"Austral Biologicals","version":"1.0","type":"link"}