Anti-Human Endogenous Retrovirus Type K (HERV K) Envelope Protein, IgG Fraction, Monoclonal

Publications using Austral Biologicals HERM-1811-5

The following scientific publications report experimental use of HERM-1811:

1. Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction. Feng et al., Cancer Research 86(14):3588-3603 (2026).
2. An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure. Xiong et al., Circulation 152(13):939-956 (2025).
3. Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM. Shek et al., Science Advances 11(35):eady8168 (2025).
4. Single-nucleus transcriptomics decodes the link between aging and lumbar disc herniation. Wang et al., Protein & Cell 16(8):667-684 (2025).
5. Resurrection of endogenous retroviruses during aging reinforces senescence. Liu et al., Cell 186(2):287-304.e26 (2023).
6. Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Taylor et al., American Journal of Respiratory and Critical Care Medicine 206(8):1019-1034 (2022).
7. Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma. Maze et al., Cancer Research 82(2):235-247 (2022).
8. A Comprehensive Analysis of Human Endogenous Retroviruses HERV-K (HML.2) from Teratocarcinoma Cell Lines and Detection of Viral Cargo in Microvesicles. Morozov and Morozov, International Journal of Molecular Sciences 22(22):12398 (2021).
9. Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers. Ko et al., BMB Reports 54(7):368-373 (2021).
10. Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines. Tatkiewicz et al., Mobile DNA 11:9 (2020).
11. Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level. Gröger et al., International Journal of Molecular Sciences 21(21):7855 (2020).
12. Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4. Foroushani et al., Proceedings of the National Academy of Sciences 117(42):26520-26530 (2020).
13. Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Turelli et al., Science Advances 6(35):eaba3200 (2020).
14. Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway. Wang et al., Proceedings of the National Academy of Sciences 117(30):17842-17853 (2020).
15. Disruption by SaCas9 Endonuclease of HERV-K env, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis. Ibba et al., Viruses 10(8):412 (2018).
16. Reconstruction of the cell entry pathway of an extinct virus. Robinson-McCarthy et al., PLOS Pathogens 14(8):e1007123 (2018).
17. Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. Fuentes et al., eLife 7:e35989 (2018).
18. Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins. Mayer et al., Molecular Neurodegeneration 13(1):39 (2018).
19. Expression of HERV-K108 envelope interferes with HIV-1 production. Terry et al., Virology 509:52-59 (2017).
20. Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein. Robinson and Whelan, Journal of Virology 90(7):3640-3649 (2016).
21. Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. Contreras-Galindo et al., Journal of Virology 89(14):7187-7201 (2015).
22. Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. Michaud et al., Journal of Immunology 193(4):1544-1548 (2014).
23. HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes. Brinzevich et al., Journal of Virology 88(11):6213-6223 (2014).
24. Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection. Michaud et al., Retrovirology 11:10 (2014).
25. Human endogenous retroviral K element encodes fusogenic activity in melanoma cells. Huang et al., Journal of Carcinogenesis 12:5 (2013).
26. Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system. Kraus et al., PLOS ONE 8(8):e72756 (2013).
27. Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. Contreras-Galindo et al., Journal of Virology 86(1):262-276 (2012).
28. HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. Jones et al., Journal of Clinical Investigation 122(12):4473-4489 (2012).
29. Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. Sacha et al., Journal of Immunology 189(3):1467-1479 (2012).
30. Human endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta. Kämmerer et al., Journal of Reproductive Immunology 91(1-2):1-8 (2011).
31. Reconstitution of the ancestral glycoprotein of human endogenous retrovirus K and modulation of its functional activity by truncation of the cytoplasmic domain. Hanke et al., Journal of Virology 83(24):12790-12800 (2009).
32. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Serafino et al., Experimental Cell Research 315(5):849-862 (2009).
33. Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer. Contreras-Galindo et al., Journal of Virology 82(19):9329-9336 (2008).