{"product_id":"gf-240","title":"Transforming Growth Factor Beta-2 (TGF-Beta 2), Human Recombinant","description":"\u003cp\u003eHuman Transforming Growth Factor beta2 (TGF-beta 2) is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. Mature TGF- beta2 is a disulfide-linked homodimer of two chains composed of 112 amino acid residues each. There is a 70% homology between human TGF- beta2 and human TGF- beta1. Human TGF- beta2 is produced in genetically engineered e. coli bacteria, and purified by sequential chromatography.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 25 kDa (dimeric protein)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Over 98% pure by non-reduced SDS gel electrophoresis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -80°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Several months at -80°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e The biological activity of human TGF-\u0026amp;# beta2 is determined by measuring the acidification of the culture medium (Rat-1 cells) exposed to the growth factor.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e 1 mg\/mL (pH 2.5). CAUTION: Since the volume supplied is small, we advise our customers to dilute this material to a working stock solution. To remove partial aliquots in not recommended.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Moustakas, A., Lin, H.Y., Henis, Y.I., Plamondon, J., O'Conner-McCourt, M.D., and Lodish, H.F., (1993) The Journal of Biological Chemistry, Vol 268, 30, October, 22215-22218.\u003cbr\u003e2. Geiser, A.G., Burmester, J.K., Webbink, R., Roberts, A.B., and Sporn, M.B., (1992). The Journal of Biological Chemistry, Vol 267, 4, February, 2588-2593.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-gf-240\"\u003ePublications using Austral Biologicals GF-240\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report use of TGF-β2 from Austral Biologicals:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-2476\" rel=\"noopener\" target=\"_blank\"\u003eTrastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMimura et al., Clinical Cancer Research 11(13):4898-4904 (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/S0002-9440(10)64803-1\" rel=\"noopener\" target=\"_blank\"\u003eKeloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eChodon et al., American Journal of Pathology 157(5):1661-1669 (2000).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.2176\/nmc.36.789\" rel=\"noopener\" target=\"_blank\"\u003eTransforming growth factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eNaganuma et al., Neurologia Medico-Chirurgica 36(11):789-795 (1996).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1136\/ard.55.3.181\" rel=\"noopener\" target=\"_blank\"\u003eEffects of transforming growth factor betas and basic fibroblast growth factor on articular chondrocytes obtained from immobilised rabbit knees\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eOkazaki et al., Annals of the Rheumatic Diseases 55(3):181-186 (1996).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1136\/bjo.80.1.63\" rel=\"noopener\" target=\"_blank\"\u003eEffects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eNishi et al., British Journal of Ophthalmology 80(1):63-68 (1996).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1002\/jcp.1041650215\" rel=\"noopener\" target=\"_blank\"\u003eCharacterization of transforming growth factor-beta growth regulatory effects and receptors on bovine mammary cells\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eWoodward et al., Journal of Cellular Physiology 165(2):339-348 (1995).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1136\/bjo.79.10.934\" rel=\"noopener\" target=\"_blank\"\u003eEffect of the cytokines on the prostaglandin E2 synthesis by lens epithelial cells of human cataracts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eNishi et al., British Journal of Ophthalmology 79(10):934-938 (1995).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1091\/mbc.3.11.1295\" rel=\"noopener\" target=\"_blank\"\u003eCharacterization of transforming growth factor-beta (TGF-beta) receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMitchell et al., Molecular Biology of the Cell 3(11):1295-1307 (1992).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_GF-240_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"5 µg","offer_id":52518874710318,"sku":"GF-240-2","price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-gf-240-5ug.png?v=1788008646","url":"https:\/\/www.australbiologicals.com\/products\/gf-240","provider":"Austral Biologicals","version":"1.0","type":"link"}