{"product_id":"gf-060","title":"Insulin-Like Growth Factor II (IGF-II), Human Recombinant","description":"\u003cp\u003eHuman IGF-II is a potent mitogen for cells of mesodermal origin. It is composed of 67 amino acid residues, and is 62% homologous with human IGF-I. Human IGF-II is produced by genetically engineered yeast, and purified by sequential chromatography.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 7.5 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Over 95% pure by N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at +4°C. Reconstitution is best in water or buffer near neutral pH. After reconstitution, storage in aliquots at -80°C is recommended.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Several months at +4°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e The material is fully active as determined by the receptor-binding assay using a membrane preparation from placenta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Modern Concepts of Insulin-Like Growth Factor. Ed. E. Martin Spencer, M.D. (1991). Elsevier Science Publ. (New York).\u003cbr\u003e2. Nissley, S. P. and Rechler, M. M. (1984). Insulin-like growth factors: biosynthesis, receptors, and carrier proteins. In C. H. Li (Ed.), Hormonal Proteins and Peptides, Vol. 12, pp. 127-203. Academic Press.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use\"\u003e\n\u003ch3 id=\"ab-published-use-gf-060\"\u003ePublished product use\u003c\/h3\u003e\n\u003cp\u003eA peer-reviewed study reported use of Austral-supplied IGF-II in cell-signaling experiments:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell signaling and adhesion assays:\u003c\/strong\u003e The study reports using IGF-II purchased from Austral Biologics in experiments examining integrin-dependent IGF receptor signaling. \u003ca href=\"https:\/\/doi.org\/10.1083\/jcb.200403003\" rel=\"noopener\" target=\"_blank\"\u003eGoel et al., Journal of Cell Biology (2004)\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_GF-060_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518874382638,"sku":"GF-060-5","price":300.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":52518874415406,"sku":"GF-060-8","price":500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-gf-060-100ug.png?v=1788008657","url":"https:\/\/www.australbiologicals.com\/products\/gf-060","provider":"Austral Biologicals","version":"1.0","type":"link"}