Insulin-Like Growth Factor II (IGF-II), Human Recombinant
100 µg
$300.00
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Insulin-Like Growth Factor II (IGF-II), Human Recombinant
Catalog no.
GF-060-5
$300.00
Human IGF-II is a potent mitogen for cells of mesodermal origin. It is composed of 67 amino acid residues, and is 62% homologous with human IGF-I. Human IGF-II is produced by genetically engineered yeast, and purified by sequential chromatography.
- Molecular weight: 7.5 kDa
- Purity: Over 95% pure by N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis.
- Storage: Store at +4°C. Reconstitution is best in water or buffer near neutral pH. After reconstitution, storage in aliquots at -80°C is recommended.
- Stability: Several months at +4°C.
- Biological activity: The material is fully active as determined by the receptor-binding assay using a membrane preparation from placenta.
- Formulation: Lyophilized powder
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References:
1. Modern Concepts of Insulin-Like Growth Factor. Ed. E. Martin Spencer, M.D. (1991). Elsevier Science Publ. (New York).
2. Nissley, S. P. and Rechler, M. M. (1984). Insulin-like growth factors: biosynthesis, receptors, and carrier proteins. In C. H. Li (Ed.), Hormonal Proteins and Peptides, Vol. 12, pp. 127-203. Academic Press.
Published product use
A peer-reviewed study reported use of Austral-supplied IGF-II in cell-signaling experiments:
- Cell signaling and adhesion assays: The study reports using IGF-II purchased from Austral Biologics in experiments examining integrin-dependent IGF receptor signaling. Goel et al., Journal of Cell Biology (2004).