{"product_id":"gf-050","title":"Insulin-Like Growth Factor I (IGF-I), Human Recombinant","description":"\u003cp\u003eHuman IGF-I is a potent mitogen for mesenchymally-derived cells. It is composed of 70 amino acid residues, and is 62% homologous with human IGF-II. Human IGF-I is produced by genetically engineered yeast, and purified by sequential chromatography.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 7.5 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Over 95% pure by N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at +4°C. Reconstitution is best in water or buffer near neutral pH. After reconstitution, storage in aliquots at -80°C is recommended.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Several months, lyophilized or in solution, at pH 6-7 and +4°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e The material is active in a receptor-binding assay using a membrane preparation from placenta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Lyophilized powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003e1. Modern Concepts of Insulin-Like Growth Factor. Ed. E. Martin Spencer, M.D. (1991). Elsevier Science Publ. (New York).\u003cbr\u003e2 D'Ercole, A.J. (1987) J. Dev. Physiol. 9:481-495\u003cbr\u003e3. Daughaday, W.H. and Rotwein, P. (1989) Endocr. Rev. 10:68-91\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- AB_PUBLISHED_USE_START --\u003e\n\u003csection class=\"ab-published-use ab-published-use-complete\"\u003e\n\u003ch3 id=\"ab-published-use-gf-050\"\u003ePublications using Austral Biologicals GF-050\u003c\/h3\u003e\n\u003cp\u003eThe following scientific publications report use of Austral Biologicals GF-050:\u003c\/p\u003e\n\u003col class=\"ab-publication-list ab-publication-list-complete\"\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.athplu.2024.09.001\" rel=\"noopener\" target=\"_blank\"\u003eThe pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGude et al., Atherosclerosis Plus (2024).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2023.05.004\" rel=\"noopener\" target=\"_blank\"\u003eAge and oxidative stress regulate Nrf2 homeostasis in human articular chondrocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eTaylor et al., Osteoarthritis and Cartilage (2023).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2023.04.006\" rel=\"noopener\" target=\"_blank\"\u003eYes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eCui et al., Osteoarthritis and Cartilage (2023).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4236\/ojas.2022.123031\" rel=\"noopener\" target=\"_blank\"\u003eEvaluation of the Hypothalamic Kisspeptin System during the Attainment of Puberty in Gilts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eClapper et al., Open Journal of Animal Sciences 12:407-427 (2022).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4236\/ojas.2021.114040\" rel=\"noopener\" target=\"_blank\"\u003eEvaluation of the Hypothalamic Kisspeptin System throughout the Estrous Cycle in Gilts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eClapper et al., Open Journal of Animal Sciences 11:591-607 (2021).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3390\/ani10101766\" rel=\"noopener\" target=\"_blank\"\u003eBedding Application to Feedlot Steers: Influence on Growth Performance, Estimated Maintenance Coefficient, Carcass Characteristics, and Circulating Metabolites in Beef Steers\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSmerchek et al., Animals 10:1766 (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1093\/tas\/txaa158\" rel=\"noopener\" target=\"_blank\"\u003eEffects of increasing doses of trenbolone acetate and estradiol on finishing phase growth performance, carcass trait responses, and serum metabolites in beef steers following implantation\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSmerchek et al., Translational Animal Science (2020).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.ijcem.com\/files\/ijcem0092842.pdf\" rel=\"noopener\" target=\"_blank\"\u003eIGF-1 increases production of extracellular matrix in human endplate chondrocytes via distinct signaling pathways\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eZhang et al., International Journal of Clinical and Experimental Medicine 12:8831-8838 (2019).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2018.12.010\" rel=\"noopener\" target=\"_blank\"\u003eArticular chondrocytes isolated from knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eCollins et al., Osteoarthritis and Cartilage (2019).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1073\/pnas.1719278115\" rel=\"noopener\" target=\"_blank\"\u003eThe ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eYounis et al., Proceedings of the National Academy of Sciences 115:E2048-E2057 (2018).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2017.05.011\" rel=\"noopener\" target=\"_blank\"\u003eHigh fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eNazli et al., Osteoarthritis and Cartilage 25:1516-1521 (2017).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2016-11893\" rel=\"noopener\" target=\"_blank\"\u003eEffects of cinnamaldehyde or monensin on performance of weaned Holstein dairy heifers\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eChapman et al., Journal of Dairy Science (2017).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2016-11221\" rel=\"noopener\" target=\"_blank\"\u003eGrowth performance of calves fed microbially enhanced soy protein in pelleted starters\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSenevirathne et al., Journal of Dairy Science (2017).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2016-10876\" rel=\"noopener\" target=\"_blank\"\u003eEvaluation of camelina meal as a feedstuff for growing dairy heifers\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eLawrence et al., Journal of Dairy Science (2016).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0150453\" rel=\"noopener\" target=\"_blank\"\u003ePotency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eJanssen et al., PLOS ONE 11:e0150453 (2016).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2015-10197\" rel=\"noopener\" target=\"_blank\"\u003eEffects of feeding rumen-degradable valine on milk production in late-lactating dairy cows\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eHultquist and Casper, Journal of Dairy Science (2016).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2014-9163\" rel=\"noopener\" target=\"_blank\"\u003eFeeding fat from distillers dried grains with solubles to dairy heifers: II. Effects on metabolic profile\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eAnderson et al., Journal of Dairy Science (2015).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2015.01.014\" rel=\"noopener\" target=\"_blank\"\u003eFunction of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGreene and Loeser, Osteoarthritis and Cartilage (2015).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.4236\/ojas.2015.52019\" rel=\"noopener\" target=\"_blank\"\u003eEffects of Short Term Administration of Genistein on Hypothalamic and Anterior Pituitary Hormones in Ovariectomized Gilts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eClapper and Paulson, Open Journal of Animal Sciences 5:163-173 (2015).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0102252\" rel=\"noopener\" target=\"_blank\"\u003eIGF-IR signal transduction protein content and its activation by IGF-I in human placentas: relationship with gestational age and birth weight\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eIñiguez et al., PLOS ONE 9:e102252 (2014).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0063838\" rel=\"noopener\" target=\"_blank\"\u003eDeficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eThakur et al., PLOS ONE 8:e63838 (2013).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.2337\/db12-1773\" rel=\"noopener\" target=\"_blank\"\u003eConcentrations of insulin glargine and its metabolites during long-term insulin therapy in type 2 diabetic patients and comparison of effects of insulin glargine, its metabolites, IGF-I, and human insulin on insulin and IGF-I receptor signaling\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eVarewijck et al., Diabetes 62:2539-2544 (2013).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1186\/ar3705\" rel=\"noopener\" target=\"_blank\"\u003eExtracellular nicotinamide phosphoribosyltransferase (NAMPT\/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eYammani et al., Arthritis Research \u0026amp; Therapy 14:R23 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1007\/s00125-011-2435-7\" rel=\"noopener\" target=\"_blank\"\u003eAddition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eVarewijck et al., Diabetologia 55:1186-1194 (2012).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0026891\" rel=\"noopener\" target=\"_blank\"\u003eDoes reduced IGF-1R signaling in Igf1r+\/- mice alter aging?\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eBokov et al., PLOS ONE 6:e26891 (2011).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpregu.00535.2010\" rel=\"noopener\" target=\"_blank\"\u003eIGF-I\/PI3K\/Akt and IGF-I\/MAPK\/ERK pathways in vivo in skeletal muscle are regulated by nutrition and contribute to somatic growth in the fine flounder\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eFuentes et al., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300:R1532-R1542 (2011).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1097\/HJH.0b013e328335d291\" rel=\"noopener\" target=\"_blank\"\u003eAngiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eOcaranza et al., Journal of Hypertension 28:1054-1064 (2010).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1038\/cdd.2009.150\" rel=\"noopener\" target=\"_blank\"\u003ePI3K p110α and p110β have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMatheny and Adamo, Cell Death \u0026amp; Differentiation (2010).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2009.09.100\" rel=\"noopener\" target=\"_blank\"\u003eEffects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMatheny and Adamo, Biochemical and Biophysical Research Communications 390:252-257 (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1074\/jbc.M109.056838\" rel=\"noopener\" target=\"_blank\"\u003eOxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-kinase-Akt and MEK-ERK MAPK signaling pathways\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eYin et al., Journal of Biological Chemistry (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2009.08.101\" rel=\"noopener\" target=\"_blank\"\u003eRole of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMatheny and Adamo, Biochemical and Biophysical Research Communications 389:117-121 (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1002\/art.24225\" rel=\"noopener\" target=\"_blank\"\u003eIncreased expression of the Akt\/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eCravero et al., Arthritis \u0026amp; Rheumatism (2009).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.2527\/jas.2007-0044\" rel=\"noopener\" target=\"_blank\"\u003eVascularity and expression of angiogenic factors in bovine dominant follicles during the first follicular wave\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eGrazul-Bilska et al., Journal of Animal Science (2007).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1038\/sj.bjc.6603435\" rel=\"noopener\" target=\"_blank\"\u003eNFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eYang et al., British Journal of Cancer (2006).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1016\/j.febslet.2006.05.023\" rel=\"noopener\" target=\"_blank\"\u003eHyperosmotic stress activates p65\/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eEisner et al., FEBS Letters 580:3469-3476 (2006).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpgi.00345.2005\" rel=\"noopener\" target=\"_blank\"\u003eOccupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKuemmerle, American Journal of Physiology-Gastrointestinal and Liver Physiology 290:G1194-G1202 (2006).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1677\/joe.1.06253\" rel=\"noopener\" target=\"_blank\"\u003eEffects of decreased estradiol-17β on the serum and anterior pituitary IGF-I system in pigs\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eHilleson-Gayne and Clapper, Journal of Endocrinology (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1530\/eje.1.02028\" rel=\"noopener\" target=\"_blank\"\u003ePro- and mature IGF-II during diet-induced weight loss in obese subjects\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eEspelund et al., European Journal of Endocrinology (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1083\/jcb.200503088\" rel=\"noopener\" target=\"_blank\"\u003eThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eLuo et al., Journal of Cell Biology (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1128\/MCB.25.7.2593-2606.2005\" rel=\"noopener\" target=\"_blank\"\u003eRole of Phosphoinositide 3-Kinase Regulatory Isoforms in Development and Actin Rearrangement\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eBrachmann et al., Molecular and Cellular Biology 25:2593-2606 (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1210\/jc.2004-1314\" rel=\"noopener\" target=\"_blank\"\u003eTestosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I\/IGFBP-1 concentrations\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eVeldhuis et al., Journal of Clinical Endocrinology \u0026amp; Metabolism 90:2941-2947 (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpgi.00032.2004\" rel=\"noopener\" target=\"_blank\"\u003eEndogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3β activity\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eKuemmerle, American Journal of Physiology-Gastrointestinal and Liver Physiology 288:G101-G110 (2005).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1210\/en.2003-1476\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-Like Growth Factor-Induced Transcriptional Activity of the Skeletal α-Actin Gene Is Regulated by Signaling Mechanisms Linked to Voltage-Gated Calcium Channels during Myoblast Differentiation\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eSpangenburg et al., Endocrinology 145:2054-2063 (2004).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1074\/jbc.M311604200\" rel=\"noopener\" target=\"_blank\"\u003eInsulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eIbarra et al., Journal of Biological Chemistry (2004).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1038\/sj.onc.1207197\" rel=\"noopener\" target=\"_blank\"\u003ePhosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eAki et al., Oncogene (2003).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1097\/01.WCB.0000087091.01171.AE\" rel=\"noopener\" target=\"_blank\"\u003eNeuroprotective Effects of Insulin-Like Growth Factor-Binding Protein Ligand Inhibitors in Vitro and in Vivo\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eMackay et al., Journal of Cerebral Blood Flow \u0026amp; Metabolism 23:1160-1167 (2003).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpendo.00410.2002\" rel=\"noopener\" target=\"_blank\"\u003eA highly sensitive and specific assay for determination of IGF-I bioactivity in human serum\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eChen et al., American Journal of Physiology-Endocrinology and Metabolism 284:E1149-E1155 (2003).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/doi.org\/10.2527\/2002.801214x\" rel=\"noopener\" target=\"_blank\"\u003eAdministration of estradiol-17β increases anterior pituitary IGF-I 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class=\"ab-publication-citation\"\u003eKöse et al., Journal of Cellular Physiology 166:188-197 (1996).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/aacrjournals.org\/cellgrowth\/article\/5\/7\/697\/495745\/\" rel=\"noopener\" target=\"_blank\"\u003ec-erbA and v-erbA modulate growth and gene expression of a mouse glial precursor cell line\u003c\/a\u003e. \u003cspan class=\"ab-publication-citation\"\u003eIglesias et al., Cell Growth \u0026amp; Differentiation 5:697-704 (1994).\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/section\u003e\n\u003c!-- AB_PUBLISHED_USE_END --\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_GF-050_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"10 µg","offer_id":52524651446574,"sku":"GF-050-1","price":100.0,"currency_code":"USD","in_stock":true},{"title":"50 µg","offer_id":52518874317102,"sku":"GF-050-4","price":80.0,"currency_code":"USD","in_stock":true},{"title":"500 µg","offer_id":52518874349870,"sku":"GF-050-8","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":52524651479342,"sku":"GF-050-10","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-gf-050-50ug.png?v=1788008668","url":"https:\/\/www.australbiologicals.com\/products\/gf-050","provider":"Austral Biologicals","version":"1.0","type":"link"}