{"product_id":"fm-122ax","title":"Anti-Infectious Salmon Anemia Virus (ISAV) Hemagglutinin-Esterease Protein, IgG Fraction, Monoclonal, Clone 8D2\/E9","description":"\u003cp\u003eMouse monoclonal antibody IgG fraction (clone 8D2\/E9) obtained by immunizing mice with a purified N-terminal hemagglutinin recombinant fragment of ISAV. The IgG fraction was purified using Protein G-Sepharose.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Stable at least one year at -20°C. Avoid repeated freezing and thawing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiological activity:\u003c\/strong\u003e This antibody can be used in ELISA (1:500 dilution), Western blot (1:1,000 dilution), and indirect immunofluorescence (1:1,000). It recognizes two bands, one at 42 kDa corresponding to ISAV hemagglutinin-esterase and the second at 90 kDa probably corresponding to a dimmer of this protein. ISAV is an enveloped virus that belongs to the family Orthomyxoviridae and genus Isavirus. Its genoma comprises eight negative-sense, single-stranded RNA segments and encodes four major structural proteins including the matrix, the nucleoprotein, and two membrane glycoproteins (hemagglutinin-esterase and gp50). ISAV infects mainly endothelial cells and leukocytes and causes a multisystemic disease characterized by high mortality with exophthalmia, pale gills, ascites, hemorrhagic liver necrosis, and renal interstitial hemorrhage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Solution at 1.0 mg\/mL in PBS.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReferences:\u003cbr\u003e\u003c\/strong\u003e\u003cbr\u003e1. \u003cmeta charset=\"UTF-8\"\u003e\n\u003cspan\u003eKrossøy\u003c\/span\u003e, B. et al. (2001) J. Gen. Virol. 82, 1757-1765.\u003cbr\u003e2. Rimstad, E. \u0026amp; Mjaaland, S. (2002) APMIS 110, 273-282.\u003cbr\u003e3. Falk,K. et al. (2004) J. Virol. 78, 3063-3071.\u003cbr\u003e4. Aspehaug, V. et al. (2004) Virus Res. 106, 51-60.\u003cbr\u003e5. Goic, B. et al. (2008) Virology 379, 55-63.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ab-datasheet-link\"\u003e\u003ca href=\"https:\/\/helix-chartreuse-ypja.squarespace.com\/s\/Austral_Biologicals_FM-122AX_Datasheet.pdf\" rel=\"noopener\" target=\"_blank\"\u003e\u003cstrong\u003eDownload technical datasheet (PDF)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"Austral Biologicals","offers":[{"title":"100 µg","offer_id":52518873792814,"sku":"FM-122AX-5","price":425.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1006\/2846\/3918\/files\/austral-biologicals-fm-122ax-100ug.png?v=1788008687","url":"https:\/\/www.australbiologicals.com\/products\/fm-122ax","provider":"Austral Biologicals","version":"1.0","type":"link"}