AUSTRAL Biologicals Catalog

Product Sheet: Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)

Catalog NumberMR-441-4
Product IdMR-441-4
Product NameAnti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryMonoclonal Antibodies (Growth Factors/Cytokines/Receptors)
DescriptionIgG fraction from mouse monoclonal antibody (clone 6B1/E7) obtained by immunization of mice with the extra-cellular domain of interleukin 4 receptor alpha chain (38 kDa). The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used for ELISA assay (1:2,000 dilution). The IL-4R alpha chain binds both IL-4 and IL-13 and activates many common signal transduction pathways. The extra-cellular domain, also called CD124, inhibits IL-4-mediated cell proliferation and IL-5 up-regulation by T-cells. The IL-4/IL-13 responses are involved in the regulation of the differentiation of CD4+ T cells and class switching to IgG1 and IgE.
FormulationSolution at 0.95 mg/mL in PBS
ReferencesNelms, K. et. al. (1999) Annu. Rev. Immunol. 17, 701 - 738
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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