AUSTRAL Biologicals Catalog

Product Sheet: Anti-Excision Repair Cross Complement (ERCC2). IgG fraction (monoclonal)

Catalog NumberTM-021Z-55
Product IdTM-021Z-55
Product NameAnti-Excision Repair Cross Complement (ERCC2). IgG fraction (monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 2A10/E2) obtained by immunization of mice with a peptide of ERCC2 (80 kDa subunit of TFIIH). The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used for ELISA assay (1:8,000 dilution). It recognizes ERCC2 subunit of TFIIH and it has not cross reaction with ERCC3 subunit. ERCC2 is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH transcription factor. It is involved in nucleotide excision repair of DNA by opening around the damage, and the initiation of transcription catalyzed by RNA polymerase II.
FormulationSolution at 0.5 mg/mL in PBS
ReferencesSchultz, P. et. al. (2000) Cell 105, 599 - 607.
Reardon, J.T. et. al. (1996) Proc. Natl. Acad. Sci. USA 93 6482-
Drapkin, R. et al (1994) Nature 368, 769 - 772.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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