AUSTRAL Biologicals Catalog

Product Sheet: Anti-human Sirtuin type 3 (Sirt 3). IgG fraction (monoclonal)

Catalog NumberTM-511-55
Product IdTM-511-55
Product NameAnti-human Sirtuin type 3 (Sirt 3). IgG fraction (monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 2D2/H11) obtained by immunization of mice with an ovalbumin-conjugated synthetic peptide corresponding to aa28 - aa77 of human silent information regulator 2 homolog (Sirt3). The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used for ELISA assay (1:2,000 dilution). It recognizes Sirt3, a mitochondrial NAD-dependent deacetylase, enzyme involved in the constitutive deacetylation of one or several mitochondrial proteins. The Sirtuin 3 activity could play an important role in the mechanism of the acetylation control of factors directly involved in apoptotic pathways.
FormulationSolution at 0.5 mg/mL in PBS
ReferencesSchwer, B. et. al. (2002) J. Cell Biol. 158, 647 - 657.
Smith, J.S. et. al. (2002) Methods Enzymol. 353, 282 - 300.
Frye, R. (2000) Biochem. Biophys. Res. Commun. 273, 793 - 798.
Frye, R. (1999) Biochem. Biophys. Res. Commun. 260, 273 - 279.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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