AUSTRAL Biologicals Catalog

Product Sheet: Anti- human Sirtuin type 1 (SIRT 1) IgG fraction (monoclonal)

Catalog NumberTM-501-55
Product IdTM-501-55
Product NameAnti- human Sirtuin type 1 (SIRT 1) IgG fraction (monoclonal)
CategoryProteins and Antibodies for Transcription Research
SubcategoryProteins and Antibodies
DescriptionIgG fraction from mouse monoclonal antibody (clone 3H2/G8) obtained by immunization using an ovalbumin-conjugated synthetic peptide corresponding to aa551–aa599 of human silent information regulator 2 homolog (Sirt1) protein. The IgG fraction was purified using Protein G-Sepharose.
StorageStore at -20°C.
StabilityStable for at least one year. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used for ELISA assay (1: 8,000 dilution), immunoblot and immunoprecipitation analysis. It recognizes Sirt1 (120kDa), a NAD-dependent p53 deacetylase; protein involved in diverse processes ranging from regulation of gene silencing to DNA damage response in mammalian cells.
FormulationSolution at 1.0 mg/mL in PBS (pH 7.2).
ReferencesLangley, E. et al. (2002) EMBO J. 21, 2383 – 2396.
Vaziri, H. et al. (2001) Cell 107, 149 – 159.
Frye, R. (1999) Biochem. Biophys. Res. Commun. 260, 273 – 279.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

top | home