AUSTRAL Biologicals Catalog

Product Sheet: Human recombinant MIP-1 alpha

Catalog NumberMI-290-3
Product IdMI-290-3
Product NameHuman recombinant MIP-1 alpha
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryMacrophage Inflammatory Proteins
DescriptionMacrophage Inflammatory Protein-1( (MIP-1 alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1 alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1 alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1 alpha is composed of 69 amino acid residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1 alpha is 60% homologous with human MIP-1 beta, 75% homologous with murine MIP-1 alpha, and has been shown to be active on murine cells. Human recombinant MIP-1 alpha is produced in genetically engineered yeast, and purified by sequential chromatography.
Mol Weight8 KDa
PurityOver 95% pure by SDS gel electrophoresis, with low level of endotoxin.
StorageStore at -80°C.
StabilitySeveral months at -80°C.
Biological ActivityThe biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.
FormulationIn water at a concentration of 1.0 mg protein/ml
References1Nathan, C.F. (1987)J. Clin. Invest. 79:319
2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612
3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911
2. Dunlop, et al (1992) Blood 79: 2221
3. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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