Bishop Ranch 6
2410 Camino Ramon, Suite 163
San Ramon, CA 94583
Tel: 925-543-0018 Toll Free: 800-433-7105
Fax: 925-275-2136

AUSTRAL Biologicals Catalog

Product Sheet: Anti-Glycoprotein 1 of Puumula virus (PUUV). IgG fraction monoclonal antibody. Clone 7C8/F12

Catalog NumberHNM-6062AZ1-5
Product NameAnti-Glycoprotein 1 of Puumula virus (PUUV). IgG fraction monoclonal antibody. Clone 7C8/F12
CategoryInfectious Agents
DescriptionMouse monoclonal antibody IgG fraction (clone 7C8/F12) obtained by immunizing mice with purified recombinant PUUV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used in ELISA (1:10,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes G1 glycoprotein of PUUV and it has cross reactivity with Dobrava virus (DOBV), Puumula virus (PUUV), Sin Nombre virus (SNV) and Andes virus (ANDV). Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. PUUV is a causative agent of a mild form of hemorrhagic fever with renal syndrome (nephropathia epidemica) mainly in Europe and it is transmitted by the red bank vole Clethrionomys glareolus.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesPlyusnin, A. et al (2001) Adv. Virus Res. 57, 105-136.
Sironen, T. et al. (2001) J. Virol. 75, 11803-11810.
Giebel, L.B. et al. (1989) Virology 172, 498-505.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

©1997-2020 AUSTRAL Biologicals Online|design + programming mcart group|Updated: 2017-01-13 10:22 GMT|