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AUSTRAL Biologicals Catalog

Product Sheet: Anti-Glycoprotein 1 of Seoul virus (SEOV). IgG fraction monoclonal antibody. Clone 2C8/B11

Catalog NumberHNM-6042AZ1-5
Product NameAnti-Glycoprotein 1 of Seoul virus (SEOV). IgG fraction monoclonal antibody. Clone 2C8/B11
CategoryInfectious Agents
DescriptionMouse monoclonal antibody IgG fraction (clone 2C8/B11) obtained by immunizing mice with purified recombinant SEOV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used in ELISA (1:10,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of SEOV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. SEOV is a hantavirus causing a mild to moderate form of hemorrhagic fever with renal syndrome that is distributed mainly in Asia and Europe. It is transmitted by the rodents Rattus rattus and Rattus norvegicus.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesZhang, Y-Z et al. (2009) Emerg. Infect. Dis. 15, 200-206.
Lokugamage, N. et al. (2004) Microbiol. Immunol. 48, 843-851.
Kim, Y.S. et al. (1995) Nephon 71, 419-427.
Antic, D. et al. (1991) Virus Res. 19, 47-58.
Arikawa, J. et al. (1990) Virology 176, 114-125.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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