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AUSTRAL Biologicals Catalog

Product Sheet: Anti-Glycoprotein 1 of Dobrava Virus (DOBV). IgG fraction monoclonal antibody. Clone 1A1/G12

Catalog NumberHNM-6032AZ1-5
Product NameAnti-Glycoprotein 1 of Dobrava Virus (DOBV). IgG fraction monoclonal antibody. Clone 1A1/G12
CategoryInfectious Agents
DescriptionMouse monoclonal antibody IgG fraction (clone 1A1/G12) obtained by immunizing mice with purified recombinant DOBV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis antibody can be used in ELISA (1:30,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically the G1 glycoprotein of DOBV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. DOBV causes hemorrhagic fever with renal syndrome in eastern and central Europe and is carried by two different rodent species, Apodemus flavicollis and Apodemus agrarius.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesKlempa, B. et al. (2004) J. Clin. Microbiol. 42, 1322-1325.
Vapalahti, O. et al (2003) Lancet Infect. Dis. 3, 653-661.
Sibold, C. et al (2001) J. Med. Virol. 63, 158-167.
Avsic-Zupanc, T. et al. (1995) J. Gen. Virol. 76, 2801-2808.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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