AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Kaiso IgG fraction polyclonal antibody

Catalog NumberPT-5030a-9
Product IdPT-5030a-9
Product NameRabbit anti-Human Kaiso IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Transcription Factors)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DGSTEFEFIIPESY) corresponding to amino acids 660-673 of human Kaiso. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1:50 dilution) using the immunizing peptide. Kaiso is a transcriptional represor that belongs to POZ-zinc finger family of transcription factors implicated in development and cancer. It binds to specific methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and it also binds to non-methylated consensus sequence 5'-CTGCNA-3'. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of represive chromatin structures in taget gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesDaniel, J.M. & Reynolds, A.B. (1999) Mol. Cell. Biol. 19, 3614-3623. Soubry, A. et al. (2005) Cancer Res. 65, 2224-2233. Kelly, K.F. & Daniel J.M. (2006) Trends Cell. Biol. 16, 578-587. Daniel, J.M. (2007) Biochim. Biophys. Acta 1773, 59-68.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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