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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human L-Myc IgG fraction polyclonal antibody

Catalog NumberPT-5010a-9
Product IdPT-5010a-9
Product NameRabbit anti-Human L-Myc IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Transcription Factors)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (SQEEASERGPQE) corresponding to amino acids 224-235 of human L-Myc. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA and Western blot assays (1: 100 dilution) using the immunizing peptide. L-Myc is a nuclear protein with two molecular forms of 60 and 66 kDa and it plays a role in the control of cell growth, cell cycle progression, neoplasia, and apoptotic cell death. It contains a basic helix-loop-helix leucine zipper domain required for dimerization and binds DNA as an heterodimer with Max protein. Both molecular forms have been detected in some carcinoma cell lines.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesDePinho, R.A. et al. (1987) Genes & Dev. 1, 1311-1326. Nesbit, C-E. et al. (1999) Oncogene 18, 3004-3016. Knoepfler, P.S. et al. (2006) EMBO J. 25, 2723-2734.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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