AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human PARK 7 (DJ-1) IgG fraction polyclonal antibody

Catalog NumberPN-7120a-9
Product IdPN-7120a-9
Product NameRabbit anti-Human PARK 7 (DJ-1) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Neurobiology)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AAQVKAPLVLKD) corresponding to amino acids 178-189 of human PARK 7. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody can be used in ELISA (1:1,000 dilution), immunicytochemistry (1:100 dilution) and it recognizes PARK 7 (20 kDa) in Western blot of HeLa lysate(1:1,000 dilution). PARK 7, also known as DJ-1 is a highly conserved cytoplasmatic protein and acts as a positive regulator of androgen receptor-dependent transcription. The expression of PARK 7 is induced by growth signals, and it is translocated from the cytoplasm to nucleous during S-phase of the cell cycle. PARK 7 also may fuction as redox-sensitive chaperone and as sensor for oxidative stress. Mutations in PARK 7 are associated with the autosomal recessive early-onset Parkinson's disease.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesNagakubo, D. et al. (1997) Biochem. Biophys. Res. Commun. 231, 509-513. Takahashi, K. et al. (2001) J. Biol. Chem. 276, 37556-37563. Miller, D.W. et al. (2003) J. Biol. Chem. 278, 36588-36595. Cookson, M.R. (2005) Annu. Rev. Biochem. 74, 29-52. Moore, D.J. (2006) Biochem. Soc. Trans. 34, 749-753.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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