AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Amyotrophic lateral sclerosis protein 2 (ALS2) IgG fraction polyclonal antibody

Catalog NumberPN-7100a-9
Product IdPN-7100a-9
Product NameRabbit anti-Human Amyotrophic lateral sclerosis protein 2 (ALS2) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Neurobiology)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (LKACYYQIQREKLN) corresponding to amino acids 1644-1657 of human ALS2. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1: 50 dilution) using the immunizing peptide. Amyotrophic lateral sclerosis protein 2 (ALS2) or Alsin is a 184 kDa protein that contains three guanine-nucleotide exchange factor domains and may act as a GTPase regulator. ALS2 dysfunction affects endosome trafficking through a Rab5 small GTPases family-mediated mechanism. It is a causative gene for a juvenile autosomal recessive form of motor neuron diseases, including amyotrophic lateral sclerosis 2. This disorder is characterized by a progressive degeneration of the upper motor neurons of the motor cortex and the lower motor neurons of the brain stem and spinal cord.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesYang, Y. et al. (2001) Nat. Genet. 29, 160-165. Hadano, S. et al. (20001) Nat. Genet. 166-173. Chandran, J. et al. (2007) Mol. Neurobiol. 224-231. Hadano, S. et al. (2007) Neurochem. Int. 51, 74-84.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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