AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody

Catalog NumberPN-7085a-9
Product IdPN-7085a-9
Product NameRabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody
Temperature-20°C
Unit1mg
Price270
AvailabilityAvailable
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Neurobiology)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DLPNSGGEAQAKKLGNN) corresponding to amino acids 41-57 of human ERAB. The IgG fraction was purified using Protein G-Sepharose.
IsotypeN/A
Mol WeightN/A
PurityN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA and Western blot assays (1: 1,000 dilution) using the immunizing peptide. Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27 kDa protein, member of the short-chain dehydrogenase/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesYan, S.D. et al. (1997) Nature 389, 689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273, 10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451, 238-242.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.


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