| Catalog Number | PN-7060a-9 |
| Product Id | PN-7060a-9 |
| Product Name | Rabbit anti-Human UCHL1 IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Neurobiology) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing a rabbit with synthetic peptide (ASSEDTLLKDAAKVCR) corresponding to amino acids 176 - 191 of human UCHL1. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA using the immunizing peptide. UCHL1 is a thiol protease that catalyzes the hydrolysis of C-terminal of ubiquityl esters and amides to generate ubiquitin monomer. It also binds to free monomer and may prevent its degradation by lysosomes. It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 oxidation has been observed in brains of patiens with Alzheimer's and Parkinson's diseases. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Day, I.N. e. al. (1990) Biochem. J. 268, 521 - 524. Solano, S.M. et al. (2000) Ann. Neurol 47, 201 -210. Liu, Y. et. al. (2002) Cell 111, 209 -218. Nishikawa, K. et al. (2003) Biochem. Biophys. Res. Commun. 304, 176 - 183. |
