AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Parkin (Ubiquitin-protein Ligase E3) (epitope b) IgG fraction polyclonal antibody

Catalog NumberPN-7050b-9
Product IdPN-7050b-9
Product NameRabbit anti-Human Parkin (Ubiquitin-protein Ligase E3) (epitope b) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Neurobiology)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (NATGGDDPRNAAGGCERE) corresponding to amino acids 81 - 98 of human Parkin. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Parkin is a ubiquitin-protein ligase (E3) involved in the ubiquitin proteasomal pathway by participating in the removal of abnormally folded or damage protein. It is highly expressed in the brain, including the substancia nigra, and is also expressed in other tissues (heart, testis, skeletal muscle). Mutations in the parkin gene causing loss of E3 activity are responsible for autosomal recessive juvenile Parkinson's desease.
FormulationSolution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesKitada, T. et al. (1998) Nature 392, 605 - 608. Von Coelin, R. et. al. (2004) Cell Tissue Res. 318, 175 - 184.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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