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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human S-phase Kinase-associated protein 1A (Skp1) IgG fraction polyclonal antibody

Catalog NumberPCA-3040a-9
Product IdPCA-3040a-9
Product NameRabbit anti-Human S-phase Kinase-associated protein 1A (Skp1) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AQVRKENQWCEEK) corresponding to amino acids 151-163 of human Skp1 . The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1: 250 dilution) and Western blot (1:1,000 dilution) using the immunizing peptide. S-phase kinase-associated protein 1A (Skp1) is a component of the SCF ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Skp1 interacts directly with cullin 1 and F-box proteins in the SCF complex. It is also involved in the control of beta-catenin levels and the activity of beta-catenin dependent TCF transcription factors.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesSchulman, B.A. et al. (2000) Nature 408, 381-386. Zheng, N. et al. (2002) Nature 416, 703-709. Cardoso, T. & Pagano, M. (2006) Nat. Rev. Mol. Cell Biol. 5, 739-751.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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