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AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Cyclin-dependent Kinase 5 (Cdk5) (epitope b) IgG fraction polyclonal antibody

Catalog NumberPCA-3020b-9
Product IdPCA-3020b-9
Product NameRabbit anti-Human Cyclin-dependent Kinase 5 (Cdk5) (epitope b) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (KCNPVQRISAEEALQH) corresponding to amino acids 268-283 of human Cdk5. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1: 25 dilution) and Western blot (1: 100 dilution) using the immunizing peptide. Cyclin-dependent kinase 5 (Cdk5) belongs to the Ser/Thr protein kinase family. It is ubiquitously expressed in both cycling and noncycling cells but its activity is detected almost exclusively in brain extracts. Cdk5 is activated by p35 protein which is only expressed in the brain. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesPines, J. (1995) Biochem. J. 308, 697-711. Maccioni, R. et al. (2001) Eur. J. Biochem. 268, 1518-1527. O'Hare, M.J. et al. (2005) J. Neurosci. 25, 8954-8966. Angelo, M. et al. (2006) J. Neurochem. 99, 353-370.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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