AUSTRAL Biologicals Catalog

Product Sheet: Rabbit anti-Human Cyclin-dependent Kinase 4 (Cdk4) IgG fraction polyclonal antibody

Catalog NumberPCA-3010a-9
Product IdPCA-3010a-9
Product NameRabbit anti-Human Cyclin-dependent Kinase 4 (Cdk4) IgG fraction polyclonal antibody
CategoryGrowth Factors, Cytokines, Receptors and their Antibodies
SubcategoryPolyclonal Antibodies (Cancer/Apoptosis)
DescriptionIgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (QHSYLHKDEGNPE) corresponding to amino acids 291-303 of human Cdk4. The IgG fraction was purified using Protein G-Sepharose.
Mol WeightN/A
StorageStore at -20ºC.
StabilityStable at least one year at -20ºC. Avoid repeated freezing and thawing.
Biological ActivityThis polyclonal antibody reacts in ELISA (1: 250 dilution) and Western blot (1: 1,000 dilution) using the immunizing peptide. Cyclin-dependent kinase 4 (Cdk4) is a 34 kDa catalytic subunit of the protein kinase complex and belongs to the Ser/Thr protein kinase family. Cdk4 forms a complex with D-type cyclins and may regulate cell growth during G1 phase of the cell cycle. Cdk4 also associates with Cdk inhibitor p16 that down-regulates Cdk4 activity. Mutations in Cdk4 are associated with tumorigenesis of a variety of cancers.
FormulationSolution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
ReferencesKhatib, Z.A. et al. (1993) Cancer Res. 53, 5535-5541. Pines, J. (1995) Biochem. J. 308, 697-711. Bockstaele, L. et al. (2006) Cell Div. 1: 25.
All products are for research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

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